CBD has been touted for a wide variety of health issues, but the strongest scientific evidence is for its effectiveness in treating some of the. Likewise, evidence from human studies supports an anxiolytic role of CBD, but is Preclinical evidence conclusively demonstrates CBD's efficacy in reducing. Evidence on efficacy of medicinal cannabis is mixed, strong for some . Cancer. The anti cancer properties of THC, CBD, CBG and other cannabinoids are well.
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Thus, cannabinoids help protect brain cells from damage, keeping the organ healthy and functioning properly. CBD has also been shown to have an anti-inflammatory effect on the brain. As the brain ages, the creation of new neurons slows down significantly. In order to maintain brain health and prevent degenerative diseases, new cells need to be continuously created.
A study showed that low doses of CBD- and THC-like cannabinoids encouraged the creation of new nerve cells in animal models, even in aging brains.
Cannabinoids are facilitative of the process of bone metabolism—the cycle in which old bone material is replaced by new at a rate of about 10 percent per year, crucial to maintaining strong, healthy bones over time. CBD in particular has been shown to block an enzyme that destroys bone-building compounds in the body, reducing the risk of age-related bone diseases like osteoporosis and osteoarthritis.
In both of those diseases, the body is no longer creating new bone and cartilage cells. CBD helps spur the process of new bone-cell formation, which is why it has been found to speed the healing of broken bones and, due to a stronger fracture callus, decrease the likelihood of re-fracturing the bone bones are 35—50 percent stronger than those of non-treated subjects.
Protects and Heals the Skin The skin has the highest amount and concentration of CB2 receptors in the body. When applied topically as an infused lotion, serum, oil, or salve, the antioxidant a more powerful antioxidant than vitamins E and C  in CBD oil has many benefits and can repair damage from free radicals like UV rays and environmental pollutants. Cannabinoid receptors can be found in the skin and seem to be connected to the regulation of oil production in the sebaceous glands.
In fact, historical documents show that cannabis preparations have been used for wound healing in both animals and people in a range of cultures spanning the globe and going back thousands of years. The use of concentrated cannabis and CBD oils to benefit and treat skin cancer is gaining popularity with a number of well-documented cases of people curing both melanoma and carcinoma-type skin cancers with the topical application of CBD and THC products. Best known is the case of Rick Simpson, who cured his basal cell carcinoma with cannabis oil and now has a widely distributed line of products.
Cannabis applied topically is not psychoactive. Cannabinoids have been proven to have an anti-inflammatory effect in numerous studies. CBD engages with the endocannabinoid system in many organs throughout the body, helping to reduce inflammation systemically.
The therapeutic potential is impressively wide-ranging, as inflammation is involved in a broad spectrum of diseases. The oral use of cannabis and CBD for anxiety appears in a Vedic text dated around BCE, and it is one of the most common uses of the plant across various cultures. While THC can increase anxiety in some patients, it lowers it in others. However, CBD effects have been shown to consistently reduce anxiety when present in higher concentrations in the cannabis plant.
On its own, CBD has been shown in a number of animal and human studies to lessen anxiety. The stress-reducing effect appears to be related to activity in both the limbic and paralimbic brain areas. A research review assessed a number of international studies and concluded that CBD has been shown to reduce anxiety , and in particular social anxiety, in multiple studies and called for more clinical trials.
It is suggested that patients work with a health care practitioner experienced in recommending cannabidiol or medicinal cannabis so that dosage and delivery methods can be developed and fine-tuned on an individual basis.
At the same time, educated and aware patients can be their own highly informed health consultants. For anxiety, CBD products with a ratio of High-CBD cannabinoids can be very effective in reducing chronic anxiety, treating temporary stress, and protecting the body from the physiological effects of both.
Varieties high in linalool, a terpene shared with lavender, are known to be effective for relieving anxiety. Always start with the micro dose to test sensitivity and go up as needed within the dosing range, before going to the next, until symptoms subside.
The micro to standard dose is usually recommended to treat stress and anxiety with CBD. For relief of immediate symptoms, as in a panic or anxiety attack, vaporizing or smoking work well. The medication lasts one to three hours, whereas most ingested products, including CBD oil, take thirty to sixty minutes before taking effect and last six to eight hours.
Herbal vaporizers that use the whole plant are also an effective delivery method. Sublingual sprays or tinctures taken as liquid drops take effect quickly and last longer than inhaled products. The Cannabis Health Index CHI is an evidence-based scoring system for cannabis in general, not just CBD oil effects and its effectiveness on various health issues based on currently available research data.
Using this rubric and based on eleven studies, cannabis rated in the possible-to-probable range of efficacy for treatment of anxiety. Elixinol Organic High Potency CBD Capsules Elixinol offers a highly concentrated, high-potency, organic whole-hemp plant CBD oil , which is naturally extracted with carbon dioxide and free of all synthetics and chemicals.
Whole-hemp plant extracts contain synergistic compounds that are believed to enhance the effectiveness and benefits of CBD. Clinical depression is a serious mood disorder characterized by persistent sadness and loss of interest, sometimes leading to decreased appetite and energy and suicidal thoughts. Commonly used pharmaceuticals for depression often target serotonin, a chemical messenger that is believed to act as a mood stabilizer.
The neural network of the endocannabinoid system works similarly to the way that serotonin, dopamine, and other systems do, and, according to some research, cannabinoids have an effect on serotonin levels. Whereas a low dose of THC increases serotonin, high doses cause a decrease that could worsen the condition. CBD products with a ratio of Specifically, products made with Valentine X or Electra 4 are more energizing, helping relieve depression.
When low energy is an issue, sativa or other stimulating strains can be helpful for improving energy and focus when THC can be tolerated. Varieties that are high in the terpene limonene are recommended for mood elevation. Always start with the micro dose to test sensitivity and go up as needed within the dosing range before going to the next, until symptoms subside.
The micro to standard dose is usually recommended to treat depression. Vaporized or smoked cannabis is recommended for relief of immediate symptoms, or a boost in dosage, and it can also be useful for sleep issues. The Cannabis Health Index CHI is an evidence-based scoring system for cannabis in general, not just CBD effects and its effectiveness on various health issues based on currently available research data. Using this rubric and based on twenty-one studies, cannabis rated in the possible-to-probable range of efficacy for treatment of depression.
Research in called for clinical trials to look into the effectiveness of cannabinoids for bipolar disorder manic depression. It also works on the GABA-glutamate system and the hypothalamic-pituitary-adrenal axis. Its main role is restoring balance through inhibition when levels are too high and enhancement when they are too low.
This is the most likely reason phytocannabinoids in general and CBD specifically are able to regulate depression and anxiety. The scientific inquiry into cannabis over the past several decades has confirmed that it is an effective and safe analgesic for many kinds of pain.
Of all the reasons that people use CBD today, pain is the most common. The same can be said of cannabis in general. In the United States, over seventy million people suffer from chronic pain, which is defined as experiencing over one hundred days per year of pain. Physicians differentiate between neuropathic usually chronic and nociceptive pains usually time-limited , and cannabis works on most neuropathic and many nociceptive types of pain. A number of studies have demonstrated that the endocannabinoid system is both centrally and peripherally involved in the processing of pain signals.
Cannabinoids can be used along with opioid medications, and a number of studies have demonstrated that they can reduce the amount of opioids needed, lessen the buildup of tolerance, and reduce the severity of withdrawal. It is suggested that patients work with a health care practitioner experienced in recommending CBD oil or medicinal cannabis so that dosage and delivery methods can be developed and fine-tuned on an individual basis.
Oral CBD products with a ratio of Most discussions of treating pain with CBD suggest that finding the right dosage is critical. Always start with the micro dose to test sensitivity and go up as needed within the dosing range by body weight until symptoms subside. If CBD-dominant products alone are not enough to treat a particular case, products with a higher ratio of THC are sometimes recommended to better manage pain. For day use, more stimulating, sativa varieties with higher concentrations of myrcene could be added to the formula.
In general, for pain, and especially for evening and nighttime, indica strains are favored for their relaxing, sedative effect. A person without experience with THC should use caution and titrate slowly up to higher doses. Research as well as patient feedback have indicated that, in general, a ratio of 4: THC is the most effective for both neuropathic and inflammatory pain. Each individual is different, however—for some, a 1: Chemotypes high in beta-caryophyllene, myrcene, and linalool provide additional pain relief and increase the effectiveness of other cannabinoids for analgesia.
For relief of immediate symptoms, as in a flare-up of pain, vaporizing or smoking work well. The medication effect is immediate and lasts one to three hours, whereas most ingested products take thirty to sixty minutes before taking effect faster on an empty stomach and last six to eight hours.
Sublingual sprays or tinctures taken as liquid drops also take effect quickly and last longer than inhaled products. When pain is localized, topical products can be applied. Topicals affect the cells near application and through several layers of tissue but do not cross the blood-brain barrier and are, therefore, not psychoactive.
The skin has the highest amount and concentration of CB2 receptors in the body. Some people experience side effects when taking cannabidiol CBD and there are other factors to consider before using CBD oil for pain. CBD is one of more than compounds called cannabinoids.
Unlike other cannabinoids — such as tetrahydrocannabinol THC — CBD does not produce a euphoric "high" or psychoactive effect. The human body has an endocannabinoid system ECS that receives and translates signals from cannabinoids. It produces some cannabinoids of its own, which are called endocannabinoids. The ECS helps to regulate functions such as sleep, immune-system responses, and pain.
When THC enters the body, it produces a "high" feeling by affecting the brain's endocannabinoid receptors. This activates the brain's reward system, producing pleasure chemicals such as dopamine. It is not psychoactive, meaning it does not produce a "high" or change a person's state of mind, but it influences the body to use its own endocannabinoids more effectively. Instead, it activates or inhibits other compounds in the endocannabinoid system.
For example, CBD stops the body from absorbing anandamide, a compound associated with regulating pain. So, increased levels of anandamide in the bloodstream may reduce the amount of pain a person feels.
Cannabidiol may also limit inflammation in the brain and nervous system, which may benefit people experiencing pain, insomnia , and certain immune-system responses. There are different levels of compounds found in the natural hemp or cannabis plant. How people breed the plant affects the CBD levels.
Makers of CBD oil use different methods to extract the compound. The extract is then added to a carrier oil and called CBD oil.
CBD oil comes in many different strengths, and people use it in various ways. It is best to discuss CBD oil with a doctor before using it. People have used CBD traditionally used for thousands of years to treat various types of pain, but the medical community have only recently begun to study it again.
A study in the European Journal of Pain used an animal model to see if CBD could help people with arthritis manage their pain. Researchers applied a topical gel containing CBD to rats with arthritis for 4 days. Their researchers note a significant drop in inflammation and signs of pain, without additional side effects. People using CBD oil for arthritis may find relief from their pain, but more human studies need to be done to confirm these findings.
Multiple sclerosis MS is an autoimmune disease that affects the entire body through the nerves and brain.
Muscle spasms are one of the most common symptoms of MS. These spasms can be so great they cause constant pain in some people. One report found that short-term use of CBD oil could reduce the levels of spasticity a person feels.
The results are modest, but many people reported a reduction in symptoms. More studies on humans are needed to verify these results. The same report studied CBD use for general chronic pain. Researchers compiled the results of multiple systematic reviews covering dozens of trials and studies. Their research concluded that there is substantial evidence that cannabis is an effective treatment for chronic pain in adults. A separate study in the Journal of Experimental Medicine supports these results.
This research suggests that using CBD can reduce pain and inflammation. The researchers also found that subjects were not likely to build up a tolerance to the effects of CBD, so they would not need to increase their dose continually.
They noted that cannabinoids, such as CBD, could offer helpful new treatments for people with chronic pain. In the United States, CBD oil has varying legality across different states and at a federal level, yet it currently has a range of applications and promising possibilities.
Although more research is required to confirm some uses of CBD oil, it is shaping up as a potentially promising and versatile treatment. In June , the U. As a result, dosages are currently open to interpretation, and people should treat them with caution. Anyone who wishes to use CBD should first speak to a doctor about whether it is a good idea, and how much to take. If you are using this medication, be sure to follow the doctor's advice about doses.
According to a review in Cannabis and Cannabinoid Research , the most common side effects include:. In addition, using CBD oil with other medications may make those medications more or less effective.
The review also notes that scientists have yet to study some aspects of CBD, such as its long-term effects on hormones. Further long-term studies will be helpful in determining any side effects CBD has on the body over time.
People who are considering using CBD oil should discuss this with their doctors. Doctors will want to monitor the person for any changes and make adjustments accordingly. The patient information leaflet for Epidiolex cautions that there is a risk of liver damage, lethargy, and possibly depression and thoughts of suicide, but these are true of other treatments for epilepsy, too. One study in Frontiers in Pharmacology , suggested cannabinoids' anti-inflammatory effect may reduce inflammation too much.
A large reduction in inflammation could diminish the lungs' defense system, increasing the risk of infection. Almost all research on CBD oil and pain comes from adult trials.
Experts do not recommend CBD oil for use in children, as there is little research on the effects of CBD oil on a child's developing brain. While many studies have suggested CBD oil is helpful for pain, more research is necessary, especially in long-term studies with human subjects. However, CBD oil does show a lot of potential for pain relief.
Anecdotal evidence suggests that it can be used to help manage chronic pain in many cases. CBD oil is especially promising due to its lack of intoxicating effects and a possible lower potential for side effects than many other pain medications.
People should discuss CBD oil with their doctor if they are considering using it for the first time. CBD oil is available for purchase online. CBD oil is legal in the U. Users should follow legal channels to obtain the CBD. The science is emerging to support its use, especially in a time where most people want to avoid the addicting opioids in chronic pain. Because of the changes in social acceptance for the use of the marijuana plant and the urgency to address the opioid crisis, there is funding for clinical trials.
A study found CBD was effective for chronic neuropathy pain. It may have a role in reducing inflammation as well. The individual should talk to a doctor first, start with the lowest doses possible, read the information available, and be an informed consumer.
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Cannabis, a complex plant: Different compounds and different effects on individuals. Therapeutic Advances in Psychopharmacology , 2 6 ,
Does CBD oil work for chronic pain management?
Due to the lack of clinical evidence, the level and effectiveness that CBD might have cannot be clearly stated. The review is nonetheless an. In just a few years, cannabidiol (CBD) has become immensely popular around the world. This is based on an increasing body of preclinical evidence to meet much stricter safety, quality, and effectiveness standards. "I think there's good evidence to suggest that CBD could be an effective Another Phase 2 clinical trial (to test efficacy and side effects) is.