Medical cannabis can be used to ease the pain resulting from rheumatoid arthritis (RA) and osteoarthritis (OA). Cannabinoids, like THC and. Cannabis stops arthritic inflammation like a boss. casustelefon.pw Arthritis Inflammation Damage May be Healed by Cannabis. Cannabinoids activate CB2 receptors. More. Copy link to Tweet; Embed Tweet. Cannabis Stops Arthritic Inflammation Like a Bosscasustelefon.pw
Like Arthritic a Boss Stops Inflammation Cannabis
Marijuana smoking has been postulated to contribute to the development of schizophreniform disorders [ ], besides the risk of brief psychotic features with acute use [ ], especially in the adolescent population. Diminished cognitive function in adolescent cannabis users [ ] is also an area of concern. Chronic cannabis users are also at risk of developing the amotivational syndrome, characterized by apathy, lack of activity, incoherence, blunting of cognition and affect [ 90 ].
However, all this data is from marijuana users, and not from a controlled therapeutic use of cannabinoids. It cannot be said for certain that long-term therapeutic use of cannabinoids will show the same risks. Some preclinical studies also show development of tolerance to various actions of cannabinoids [ ], including antinociception [ ]. Recreational cannabis use is associated with a withdrawal syndrome consisting of tiredness, yawning, depression, anxiety, psychomotor retardation, reported at a prevalence of Cannabinoids have been reported to cause motor impairment in the form of cerebellar incoordination [ ], and the pathway appears similar to that of ethanol induced incoordination [ ].
These concerns may need to be addressed while exploring the therapeutic use of cannabinoids. Management of severe chronic pain is best done by a multi-pronged approach, individualizing it not just according to the disease but also according to patient preferences and their side effect profiles. Currently there is intriguing evidence from animal studies showing efficacy of cannabinoids as antinociceptive agents, however data from human studies is still emerging.
Cannabinoids may form a useful adjunct to current analgesic drugs in many conditions, especially in low doses incapable of inducing hyperalgesia or other side effects. They can also be used as rescue drugs when opioid analgesia is ineffective or inadequate, or as opioid sparing agent. They also appear to antagonize several side effects of opioids, and the opioid-cannabinoid combination may become a very useful agent in the long-term management of severe pain. Preclinical data also suggest a beneficial effect of cannabinoids on the disease process in HIV, cancer, and MS.
While smoked marijuana tends to be a controversial territory, evidence points to significant multi-symptom relief from it especially in HIV patients. Cannabis derived medications deserve to be investigated in rigorously designed studies so that their role in managing severe and chronic pain in various conditions can be more clearly defined.
The legalization of medical marijuana would also enable more clinical trials in humans, and development of cannabis-derived drugs for multiple disease processes, in addition to treating severe pain. Moreover, examination of cannabinoids and their receptors may potentially lead to a new understanding of disease processes as well.
Thus, the medical, as well as the general community, need to move beyond preconceived notions about cannabis, and focus on its potential advantages in treating a host of conditions, including severe pain.
National Center for Biotechnology Information , U. Author manuscript; available in PMC Jul Author information Copyright and License information Disclaimer. This article has been corrected. See other articles in PMC that cite the published article. Abstract Historically and anecdotally cannabinoids have been used as analgesic agents. Introduction Cannabinoids are derivatives of Cannabis sativa, the hemp plant, which evolved in the temperate regions of Central Asia.
Classification of cannabinoids Based on their origin, cannabinoids are classified into 3 categories: Open in a separate window. Cannabinoid receptors and signaling pathways Cannabinoids mainly act via 2 different receptors: Routes of cannabinoid use Smoking and oral ingestion are the common routes of cannabinoid use. Cannabinoids for analgesia — animal studies a Neuropathic pain Cannabinoids have been studied in various types of neuropathic pain including nerve injury, chemotherapy-induced, diabetic neuropathy, etc.
Synergism with opioids a Experimental studies Opioids and cannabinoids both provide antinociception through G-protein coupled mechanisms, and many studies have explored synergistic interactions between them. Table 4 A comparision of opioids and cannabinoids in pain management. Shown to be not useful in acute nociceptive pain in humans [ 84 ], [ 85 ], [ 86 ].
Cannabinoids In Multiple sclerosis Many randomized clinical trials with cannabinoid medications have been conducted in multiple sclerosis MS. Agent; route; daily dose Clinical Condition Study design Number. Numerical rating scale for pain [ ]. Expanded Disability Status Scale [ ]. Clinical studies with cannabinoids in pain The trials focusing on MS and related etiologies have already been discussed above.
The Edmonton Symptom Assessment System [ ]. A THC predominant cannabis extract [ ]. Can Cannabinoids be useful in Sickle cell disease? Side effects of cannabinoids Epidemiological studies have reached diverse conclusions regarding the association of cannabis with various cancers. Conclusion Management of severe chronic pain is best done by a multi-pronged approach, individualizing it not just according to the disease but also according to patient preferences and their side effect profiles.
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Nausea, vomiting and constipation are common during opioid therapy [ 73 ]. Cannabinoids are used as anti-emetic, especially in chemotherapy induced nausea and vomiting [ 74 ]; In cases of chronic cannabis abuse, hyperemesis has been reported [ 75 ]; Constipation seen as a mild-moderate AE in some clinical trials. Chance of respiratory depression with opioid overdose, generally along with ethanol or sedative ingestion, postoperative scenario or opioid abuse; not commonly reported with the doses used in pain management [ 76 ].
Targeting the receptors in the endocannabinoid system could help strengthen the anti-inflammatory effect and perhaps be used to treat RA and OA. With the production of these compounds turned down, the immune response was also muted. Knee joint showing damage of arthritis. This is likely related to the anti-inflammatory effect, because osteoclasts are derived from macrophages, a type of immune cell. The cytokines and other signals produced in the inflammatory response help to turn macrophages into osteoclasts.
Treatment of arthritis with cannabis could, therefore, help to calm the auto-immune response, reduce the inflammation of the joint, and slow the pace of bone loss and joint destruction in RA and OA.
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Arthritis & Medical Marijuana
Stacy R Webb · @Parrottfarms. Livin' The Good Life! Western Kentucky. casustelefon.pw Joined August Arthritis may also manifest as chronic inflammation of the joints as the result of injuries. to reduce the secretion of the pro-inflammatory cytokines controlled by the . Lupus symptoms resolve when the medication is stopped. The Cannabis used 10, years ago by Taiwanese as fiber and food for Shen -Nung as a treatment for constipation, psoriatic arthritis. . In fact given the long half-life of cannabis in tissues even were a maternal habitual smoker to stop brain inflammation, axonal growth cone guidance, stem cell niche.